Will the new hair grow only
where there was once used to be hair or will they grow wherever the
cultured cells are injected regardless of whether there used to be hair or not
on the scalp ?
I
cannot give you a conclusive answer because we only tested the procedure on
areas where there was once hair.
If the cultured hair cells
exhibit the same properties, will the new hair go through the hair cycle (anagen,
catagen, telogen) all at the same time ? What are the possibilities that the new
hair will fall off simultaneously if they go through telogen all at the same
time ?
That
is a good question. So far I have not witnessed anything of this nature in my
test subjects.
Are completely new follicles
created or are old ones used with the addition of new HM cells ? The patent
seems to suggest that new follicles are induced to grow, is this accurate ? If
old follicles are induced to produce terminal hairs, what will prevent the cells
in the matrix from still reacting to DHT or whatever is ultimately
responsible for the follicle miniaturization from continuing to occur, making a
treatment only a temporary solution ?
I
cannot give you a conclusive answer unless we do separate experiment as well as
biopsies of the hair follicles. But based on the way the cultured suspension is
injected into the scalp, I would tend to think that old or dormant follicles are
being rejuvenated in the process. We are only several years into the clinical
trials. It would take many more years before we can conclude if the HM induced
regrowth will eventually be subject to whatever is responsible for follicle
miniaturization.
If old follicles are being
rejuvenated in the process, can we rejuvenate all old follicles regardless of
how long they have remained inactive ?
Based
on my test subjects' results, it appears that how long a person has been bald is
irrelevant to how well he or she will respond to HM. I have test subjects who
have been bald for a much longer period than others and ironically they also
generate better results others.
In HM, are you removing
cells from follicles in non-DHT-affected areas, culturing those cells, and then
transplanting or injecting the resulting cell lines INTO dormant follicles in
balding areas of the scalp to stimulate the cells in those dormant follicles? In
other words, does HM cause follicular neogenesis, ie: does it create brand new
hair follicles which previously did not exist, and is this the PRIMARY mechanism
by which HM grows hair ?
Please
refer to answer above.
Since you are injecting via
the pores, is the functionality of the injected pore retained after it is
injected, or is it in some way changed or damaged ?
This
is not an issue.
Do the cells injected with a
single injection disperse when injected in the scalp and form follicles in
somewhat different areas, or does each injection lead to only a single new
follicle site, even if it turns out to be a multi-lobed follicle or two
follicles jammed together etc?
Each
injection aims at delivering the cultured suspension to one hair follicle at a
time.
One of our posters has a
very creative idea. I am going to quote what he said and perhaps you can give us
your comments?
"Why
couldn't Dr. Gho simply remove the epidermis of the scalp with a laser as in
cosmetic laser resurfacing and then bathe the treated area with the stem cell
bath? In theory you should get decent diffusion through the treated surface
tissue. have seen a number of patients that have had that sort of
resurfacing and their skin looks brand new. As the tissue heals the stem cells
could possibly get "trapped" below the newly forming epidermis and
find their way to the dormant follicles. Or maybe even regrow as new follicles.
It would hurt like hell post op but you could do wide areas at one sitting and
it would be like casting seeds on newly fertile soil. Should get pretty fair and
even distribution and the density would be less a function of operator skill and
more a function of the patients innate ability to grow new follicles".
When
you only resurface the epidermis, it does not give you sufficient penetration
into the skin and the recipient area will be too superficially treated to
regenerate new hair follicle or induce new hairgrowth.
What exactly is meant by the
U.S protocol for HM? Does it refer to cell culture and tissue-handling standards
promulgated by the U.S government (FDA)? We are not asking you to reveal
proprietary information or trade secrets about your HM procedure. We are just
asking why you use the term U.S protocol. Have you already contacted the FDA or
other authority.
You
are correct. To put it very simply without offering too much details, some
materials we use for tissue engineering process are easily approved in one
country and not the other. The protocol is part of the standardization process I
am referring to all the time. I want to be able to use the exact same
procedure throughout the world and not have to worry about altering the
procedure on a region by region basis in order to meet a particular country's
demands. You can see this is a very time consuming process.
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